The Patient-Centered Outcomes Research Institute (PCORI) has approved funding grants totaling $258 million to support 26 new research studies. These studies aim to fill evidence gaps and improve healthcare decision-making for a range of high-burden conditions in adults and children, including asthma, bone fractures, migraines, intellectual and developmental disabilities and sinus infections.
Five comparative clinical effectiveness research (CER) studies focus on improving mental health and four other studies on heart disease, both of which have continued to worsen in the United States amid the pandemic of COVID-19.
In addition, PCORI today announced approximately $3.9 million for two projects that aim to promote wider and faster uptake of useful results from PCORI-funded ERC studies in typical healthcare practices.
Reflecting the priorities contained in PCORI’s recently adopted strategic plan, today’s funding approvals are an important milestone in advancing PCORI’s work to generate and disseminate information that improves data quality and relevance. evidence available to help patients and all stakeholders make more informed decisions about their health. Faced with a complex healthcare system and numerous care options, patients need reliable information to help them understand which care options will work best for them in their particular situation. »
Nakela L. Cook, MD, MPH, PCORI Executive Director
$72 million to improve mental health care and outcomes
The newly approved REB mental health studies will expand an existing strong portfolio of PCORI-funded research examining the effectiveness of mental health care options for adults and children.
A study will assess the comparative effectiveness of first- and second-line pharmacological treatment strategies used to help people with bipolar disorder who are experiencing a major depressive episode. Funded to the tune of nearly $25 million, this large study aims to include 2,800 adult participants at 38 academic medical centers and community sites across the United States.
A second study will compare the potential benefits and harms of electroconvulsive therapy and intravenous ketamine for the prompt treatment of acute suicidal depression. Funded at approximately $28.5 million, this large study aims to include 1,500 adults at 10-13 sites across the United States
A third study will assess the comparative effectiveness of two interventions, text-enhanced telehealth services and financial incentives, for increasing outpatient addiction treatment in adults with opioid use disorder after discharge. of an emergency service.
Two other studies will:
- Compare the effectiveness of in-person and technology-enhanced screening and referral programs for improving screening, referral, treatment uptake, communication, and care coordination for pregnant and postpartum people with substance use disorders.
- Compare two interventions – one involving a safety plan with follow-up contacts and the other a brief crisis-focused intervention targeting interpersonal functioning – to see if either is better at reducing suicidal ideation and attempts in English- and Spanish-speaking adolescents receiving care in urban emergency departments.
$52.5 million to improve health care and heart-related outcomes
Four newly approved CER studies will be added to PCORI’s portfolio of funded research determining the effectiveness of cardiac health care options for adults. The most important will compare two therapies used to restore normal heart rhythms in millions of patients with both heart failure and reduced ejection fraction. It aims to determine whether His or left-branch pacing or biventricular pacing offers advantages over the other. Funded at more than $31 million, the study aims to recruit more than 2,000 adults at 55 sites in the United States and Canada.
Three other studies will:
- Compare patient-centered outcomes for cardiac rehabilitation delivered via telehealth or in person for patients with chronic heart disease.
- Compare the effectiveness of two classes of antianginal drugs in older people with stable angina and multiple chronic diseases.
- Compare blood pressure outcomes among a diverse population of patients with high blood pressure who receive either telehealth-supported team care with a pharmacist or enhanced usual care with pressure monitoring equipment and instruction blood pressure at home compatible with telehealth.
$3.9 million to promote the uptake of PCORI-funded research evidence into practice
These implementation projects will focus on:
- To promote informed decision making between antibiotics and appendectomy in eligible patients with appendicitis at 15 hospitals across the United States, using a program that includes a decision support tool for the patients.
- Integrate an mHealth program, which includes a smartphone app for patients and an online dashboard for clinicians, into the routine care of three community mental health agencies to help people with serious mental illness manage their symptoms .
PCORI has also awarded funding to compare preventative therapies for migraines and bone fractures as well as several studies that focus on evaluating ways to promote healthy aging. Details of newly approved studies are available on the PCORI website.
Details of all studies and projects approved for PCORI funding to date are available on the organization’s website. All funding awards have been approved pending a review of activities and programs by PCORI staff and the issuance of formal award contracts. With these latest awards, PCORI will have invested more than $3.7 billion to fund patient-centered REC and support other projects designed to improve REC methods and the infrastructure needed to conduct REC rigorously and efficient.
Patient Centered Outcomes Research Institute